The only criteria I chose for this list is that all of my picks must have been designed with a computer system in mind as the primary platform (and have a release gap of at least three months between any console ports), or be PC-exclusive. Oh, and they have to still be fun to play today, too.
As ever, keep in mind that this are my personal picks and no-one else's. Oh, and these are by no means the only PC-built games I like. Trust me, I had quite a lot of trouble sticking to my rules and narrowing this down to only 50!
I may have also compiled a list of honorable mentions though.
50. D/Generation (Robert Cook, 1991)
49. Microsoft Flight Simulator (Asobo Studio, 2020)
Microsoft Flight Simulator is one of the longest-lived franchises in PC gaming (and gaming in general), having entries dating all the way back to 1982. The newest one as of this writing, released in 2020, took things to an entirely new level by incorporating real-life into the game in a literal form - namely, utilizing data from Bing Maps and OpenStreetMap to generate the entire world for you to fly around at your leisure, and even tracking real-time flight traffic so you could take command of virtual versions of planes that were actually in the air flying. Of course, you're hardly limited to just one type of plane - from commercial airliners to biplanes to even a remote controlled drone to check everything out at ground level, you get to try them all out, plotting your own paths or following real-life air traffic. You even get to tweak weather effects as you play, which adds a new later of challenge to the proceedings and looks awesome to boot. It does have a few weird hiccups with it's world generation (most famously a bizarre 212-story tower near Melbourne), but these are amusing rather than distracting. Microsoft Flight Simulator is an incredible achievement on a technical level, and with real life air travel as restricted as it was in 2020, it couldn't have come at a better time.
48. Jazz Jackrabbit 2 (Epic MegaGames, 1998)
persists to this day) and support for custom-made levels, giving it quite a bit of replayability. A solid exclusive title for PC proponents and still a fun game for fans of sidescrolling action.
47. Magic: The Gathering (aka Shandalar) (Microprose, 1997)
46. Out of This World (Delphine Software, 1991)
43. Shadowgate (Zojoi, 2014)
44. Sid Meier's Civilization V (Firaxis Games, 2010)
43. The Oregon Trail (MECC, 1985)
41. Fallout: A Post Nuclear Role Playing Game (Interplay, 1997)