45. Fallout: A Post Nuclear Role Playing Game (Interplay, 1997)
Drawing heavy inspiration from their earlier hit "Wasteland" (with the license having fallen to EA years prior), Fallout set out to create a bleak post-apocalyptic landscape for the player to explore, and did so admirably, combining a grim atmosphere with a sly sense of humor throughout. What really sold the game, though, was the sheer amount of thought put into its story and design - rather than encourage the player to just mindlessly blast everything as so many RPGs of the time were wont to do, the player is given many choices to deal with every questline put before them - a combatative approach, stealthy approach and even pure diplomacy will work in almost any situation. Hell, it's even possible to complete the game without firing a single shot or witnessing a single death. The first in a great series of games.
44. Sid Meier's Civilization V (Firaxis Games, 2010)
43. The Oregon Trail (MECC, 1985)