We do a bunch of fun stuff in New Reno. Suffice to say there's not much chance of coming out of here with a net gain in Karma.
A couple neat things I forgot to show:
Check the pool table next to the stairs on the second floor of Bishop's casino to find the Magic 8-Ball. Not much use unless you have a Luck stat of 9 or higher, but it's quite a bit of fun if you do. It points you to a bunch of hidden goodies that you can't access otherwise.
Uncovering a specific grave in Golgotha will also earn you the Mirrored Shades, which give you a +1 Charisma bonus if you have them equipped as your active item. Worth the Karma drop.