50. Final Fantasy III (Square, 1990 in Japan)
The last of the Final Fantasy games released for the Famicom, and definitely the best one it had there. After the relatively unpopular second entry tried to change up the gameplay and design (with not-so-great results), Final Fantasy III goes back to basics a bit, reintroducing the class system and overall aesthetic of the first while giving it a major upgrade in visual and sound fidelity. The class sytem is much more in-depth now, though, including nineteen classes in total. All the classics from the first return and many new ones are introduced that would become series mainstays, like the Ranger, Geomancer, Bard and Sage classes. A much larger world than the first two games is on display too, as are plenty of dungeons and hidden secrets to find. It's not regarded by too many people as one of the best in the franchise, but it's certainly the best you're going to find on the original Famicom.
48. Pirates! (Microprose/Rare, 1991)
Originally released in 1987 for various computer platforms, Sid Meier's Pirates was a pretty novel game for its time - a heavily randomized sandbox adventure where you choose a name, a nationality and a skill, and from there you were basically just set loose on the Caribbean to make a name for yourself. You could take on the role of a treasure hunter, a privateer, a pirate hunter, become a pirate yourself, or any combination of the above, taking part in sea battles, sword duels, city raids and treasure hunts to pursue your goals. Once you retired (whether by choice or old age) you're given a rank depending on how much gold, influence, rescued family and land you acquired over the course of your career; anywhere from becoming a lowly pauper to a king's advisor. The 1991 NES port was handled by Rare and published by Konami, and as usual they did a fantastic job - it looks and sounds great and plays smoothly while keeping everything that made the original a classic.47. Takahashi Meijin no Bouken Shima IV (Now Production, 1994 in Japan)
46. Battletoads & Double Dragon: The Ultimate Team (Rare, 1993)
One of the earliest video game crossovers I remember seeing, and at the time, it was certainly one to celebrate. One of the best beat-em-up franchises of the era alongside the ultra-tough action masterpiece Battletoads? I was definitely on-board as a fan of both. While the gameplay is primarily based on Battletoads, it puts a much heavier emphasis on its beat-em-up elements this time around, ensuring the gameplay is fast-paced, hard-hitting and consistently fun. Not to say that there are a shortage of obstacle course setpieces, of course, as you get a toned-down version of the Turbo Tunnel, a top-down shooter segment that feels like a cross between Asteroids and Solar Jetman, and some rappelling segments too. Just a fun and solidly-crafted game in general with no shortage of challenge; it's just a shame it came out so late in the system's life.
45. Bubble Bobble Part II (Taito, 1993)

44. Uninvited (ICOM, 1991)

43. Castlevania (Konami, 1987)

42. Adventure Island II/III (Now Production, 1991/1992)
Adventure Island is one branch of the Wonder Boy series that spun off into its own series of games. While Adventure Island mostly stuck to platforming, Wonder Boy branched out into numerous other genres including side-scrolling shmups and action-RPG territory, and mostly appeared on Sega consoles and the Turbografx-16 while Adventure Island primarily appeared on Nintendo consoles. They're all quite good, but Adventure Island is a fun, fast-paced platformer series with colorful graphics and some creative gameplay elements. 2 introduced the ability to store and use powerups later on (a la Mario 3) and dinosaur buddies that can breathe fire, fly, tail whip and move faster underwater (not unlike Yoshi from Super Mario World). 3 didn't add a lot of new elements to the gameplay over 2, but it was still a lot of fun, so I'm certainly not complaining.
The first in a legendary NES trilogy, Ninja Gaiden quickly became as well-known for its high production budget and gripping storyline (a rarity at the time) as for its absurd difficulty - enemy patterns start off relatively manageable, but quickly become downright vicious, requiring spot-on execution with jumps, attacks and special weapons to even have a chance of seeing it through to the end. To say nothing of the final boss gauntlet, which also requires strict adherence to a pattern and punishes the player for death by sending them all the way back to the beginning of the stage. Still, those who could persevere found a game worthy of hanging with the best in the action genre even now, almost thirty years after its original release.